Related Experiment Video
Updated: Aug 9, 2026
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
[Work on the Haemonetics 30 blood cell separator]
Bilten Za Hematologiju I Transfuziju
|January 1, 1984
Summary
High platelet and leukocyte concentrations are observed during blood cell separation, particularly when using specific solutions. Therapeutic plasmapheresis requires careful patient monitoring and appropriate plasma substitutes to manage potential complications.
Area of Science:
- Hematology
- Biomedical Engineering
Context:
- Cell separation technologies are crucial in blood banking and therapeutic apheresis.
- Understanding the composition of separated blood components is vital for optimizing procedures.
Purpose:
- To analyze the concentration of platelets and leukocytes during cell separation.
- To highlight considerations for therapeutic plasmapheresis compared to blood donation.
Summary:
- Cell separation yields high platelet concentrations (6.94 x 10^11/L) and significant leukocyte levels (1.6 x 10^10/L).
- Leukocyte concentrations increase with intravenous Dextran (Dexan) and Plasmasteril use.
- Therapeutic plasmapheresis necessitates distinct protocols from blood donation due to potential complications.
Impact:
- Informs optimal settings for cell separators to manage component yields.
- Guides clinical practice in therapeutic plasmapheresis, emphasizing patient safety.
- Highlights the influence of specific solutions on blood component separation outcomes.
