Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Bone Structure01:55

Bone Structure

51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.2K
Bone Cells and Tissue01:30

Bone Cells and Tissue

8.3K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.3K
Compact Bone01:27

Compact Bone

16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.

Cell death & disease·2014
Same author

Poly(ADP-ribose) synthesis: a useful parameter for identifying apoptotic cells.

The Histochemical journal·1998
Same author

Nuclear association of cyclin D1 in human fibroblasts: tight binding to nuclear structures and modulation by protein kinase inhibitors.

Experimental cell research·1998
Same author

Sudden death in young people with apparently isolated mitral valve prolapse.

Giornale italiano di cardiologia·1998
Same author

Use of nonvolatile buffers in liquid chromatography/mass spectrometry: advantages of capillary-scale particle beam interfacing.

Analytical chemistry·1998
Same author

Purification of a fully metal-depleted Cu, Zn superoxide dismutase from copper-deficient rat liver.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·1997

Related Experiment Videos

[Hexokinase in bone marrow cells in the rabbit].

M Magnani, L Rossi, G Bechi

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |September 30, 1984
    PubMed
    Summary

    Hexokinase Ia and Ib isozymes in reticulocytes show a consistent ratio but decreasing activity with cell maturity. Bone marrow cells have low Hexokinase Ib, absent in early erythroblasts.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Hematology

    Context:

    • Reticulocytes, immature red blood cells, are key for studying erythropoiesis.
    • Hexokinase isozymes play a critical role in cellular energy metabolism.
    • Understanding isozyme dynamics during red blood cell maturation is essential.

    Purpose:

    • To investigate the hexokinase isozymic pattern in circulating reticulocytes.
    • To analyze the distribution and activity of hexokinase Ia and Ib during reticulocyte maturation.
    • To compare hexokinase isozyme presence in bone marrow cells and early erythroblasts.

    Summary:

    • Hexokinase isozymic patterns were studied in reticulocytes fractionated by density gradient ultracentrifugation.
    • All reticulocyte fractions maintained a similar ratio of hexokinase Ia to hexokinase Ib.

    Related Experiment Videos

  • A four-fold decrease in hexokinase specific activity was observed with increasing cell density (maturation).
  • Bone marrow cells from anemic rabbits showed low levels of hexokinase Ib.
  • Hexokinase Ib was notably absent in basophilic erythroblasts, indicating its developmental regulation.

    • Impact:

    • Provides insights into the metabolic changes during late-stage erythropoiesis.
    • Highlights the differential expression and activity of hexokinase isozymes during red blood cell development.
    • Contributes to the understanding of cellular energy metabolism in differentiating hematopoietic cells.