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Calcitonin in a chronoepidemiologic perspective.

M Cecchettin, B Tarquini

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1984
    PubMed
    Summary
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    Calcitonin levels show seasonal variations in healthy women, but this rhythm is lost in breast cancer patients. This loss of rhythm may signal early disease, not just metastasis.

    Area of Science:

    • Endocrinology
    • Oncology
    • Chronobiology

    Background:

    • Calcitonin, a hormone, exhibits seasonal variations in its levels.
    • Breast cancer patients may have altered hormonal profiles.
    • The relationship between calcitonin rhythms and breast cancer progression is not well understood.

    Purpose of the Study:

    • To investigate seasonal (circannual) variations of calcitonin in healthy women and breast cancer patients.
    • To determine if calcitonin rhythm alterations correlate with breast cancer stage or metastasis.
    • To explore the potential of calcitonin rhythm obliteration as an early disease marker.

    Main Methods:

    • Studied calcitonin levels over time in apparently healthy women (controls).
    • Assessed calcitonin levels in women with breast cancer across different TNM stages.

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  • Analyzed data for seasonal patterns (circannual rhythms) and correlations with disease status.

    • Main Results:

    • Annual calcitonin values were higher in breast cancer patients compared to controls.
    • No significant correlation was found between calcitonin levels and the presence of metastases.
    • A significant circannual rhythm with a winter acrophase was observed in controls, but absent in breast cancer patients.

    Conclusions:

    • Obliteration of the calcitonin circannual rhythm is observed in breast cancer patients.
    • This rhythm disruption may serve as a predictive signal for breast cancer, independent of metastatic status.
    • Further research into calcitonin's role in cancer chronobiology is warranted.