[Cancer of the esophagus induced in the Wistar rat by ethyl-N-butyl-nitrosamine]

OEsophageal papillomas and carcinomas have been induced in Wistar rats using Ethyl-N-Butyl-Nitrosamine. None of those lesions were observed in a previous experiment on the same rats strains, with ethanol and apple brandy. Experimentally induced tumours in the rat are different from oesophageal cancers and associated mucous lesions in man. Both upper digestive mucosae are only similar in regards to their response to carcinogens.