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[Ketamine via rectal route for the induction of pediatric anesthesia]
Cahiers D'Anesthesiologie
|September 1, 1984
Insights
Rectal ketamine administration in children with congenital heart disease or pneumopathia resulted in smooth and well-tolerated induction. Full effects were observed within 9 to 25 minutes following administration.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
- Critical Care Medicine
Context:
- Congenital heart disease (CHD) in pediatric patients.
- Pneumopathia in pediatric patients.
- Challenges in pediatric anesthesia induction.
Purpose:
- To evaluate the efficacy and tolerability of rectal ketamine administration in pediatric patients.
- To determine the onset and duration of action for rectal ketamine in children.
- To assess ketamine as an anesthetic induction agent for specific pediatric populations.
Summary:
- Three pediatric groups (6 months–3 years with CHD, 4–12 years, and 14–18 years with pneumopathia) received rectal ketamine (10 mg/kg).
- Anesthesia induction was smooth and well-tolerated across all studied pediatric groups.
- The time from onset of effects (nystagmus) to full anesthetic action ranged from 9 to 25 minutes.
Impact:
- Provides evidence for the safe and effective use of rectal ketamine in specific pediatric populations.
- Offers a valuable alternative anesthetic induction method for children with complex medical conditions.
- Contributes to the understanding of ketamine pharmacokinetics and pharmacodynamics in pediatrics.
Abstract:
Three groups of children: 6 months to 3 years old with congenital heart disease, and 4 to 12 years old, and mentally retarded 14 to 18 years old affected by pneumopathia received 10 mg kg-1 ketamine by rectal administration. Induction was smooth and well tolerated. From onset of effects with nystagmus to full action 9 to 25 minutes elapsed.