Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histone H1o in developing rat brain cells.

M Stambolova, V Simeonova, L Srebreva

    Differentiation; Research in Biological Diversity
    |January 1, 1984
    PubMed
    Summary

    Histone H1o is present in mature rat brain cells, specifically neurons and oligodendrocytes. This protein is absent during early development but appears as cells differentiate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [On the possibility of histological studies on ionized groups of protoplasm].

    Izvestiia. Bulletin. Bulgarska akademiia na naukite. Institut po biologiia "Metodii Popov"·2014
    Same author

    A protein fraction stably linked to DNA in plant chromatin.

    Plant molecular biology·2013
    Same author

    Matrix-associated DNA from maize is enriched in repetitive sequences.

    Plant cell reports·2013
    Same author

    CCCTC-binding factor: to loop or to bridge.

    Cellular and molecular life sciences : CMLS·2009
    Same author

    Molecular mechanisms of cancer cells survival.

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2007
    Same author

    The archaeal histone-fold protein HMf organizes DNA into bona fide chromatin fibers.

    Structure (London, England : 1993)·2001

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Molecular Biology

    Background:

    • Histones are crucial for DNA packaging and gene regulation.
    • Histone H1 variants play roles in chromatin structure and cell differentiation.
    • The specific role of Histone H1o in brain development is not fully understood.

    Purpose of the Study:

    • To investigate the presence and localization of Histone H1o in the developing rat brain.
    • To determine the relationship between Histone H1o expression and cell differentiation in neuronal and oligodendrocyte lineages.

    Main Methods:

    • Fractionation of rat brain nuclei using sucrose-gradient isopycnic centrifugation.
    • Identification and quantification of Histone H1o in different cellular fractions.

    Main Results:

    • Histone H1o was detected in both neuronal and oligodendrocyte nuclei from rat brains.
    • Histone H1o was notably absent in brain cells during early proliferative stages.
    • Significant accumulation of Histone H1o was observed in terminally differentiated brain cells.

    Conclusions:

    • Histone H1o expression is linked to terminal differentiation in rat brain cells.
    • This histone may play a role in the maturation of neurons and oligodendrocytes.
    • Further research is warranted to elucidate the precise function of Histone H1o in neurodevelopment.

    Related Experiment Videos