Testosterone and tolerance in rat vas deferens
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Updated: Oct 12, 2026

10:28
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
Published on: December 5, 2017
General Pharmacology
|January 1, 1984
Abstract:
Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

