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A modified D-xylose absorption test.

R Weiner, R Laue, F Dietze

    Infusionstherapie Und Klinische Ernahrung
    |December 1, 1984
    PubMed
    Summary
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    A modified D-xylose test accurately assesses intestinal absorption, unaffected by kidney or liver function. This method reliably detects malabsorption in conditions like celiac disease.

    Area of Science:

    • Gastroenterology
    • Clinical Diagnostics
    • Human Physiology

    Background:

    • Assessing intestinal absorption is crucial for diagnosing gastrointestinal disorders.
    • Existing methods for evaluating intestinal absorption can be confounded by renal or hepatic function.
    • A reliable, non-invasive test is needed to specifically measure small intestine absorptive capacity.

    Purpose of the Study:

    • To describe a modified D-xylose test for assessing intestinal absorption.
    • To evaluate the test's ability to function independently of renal and hepatic function.
    • To validate the test in normal individuals and patients with coeliac disease.

    Main Methods:

    • Oral and intravenous administration of D-xylose.
    • Graphic-mathematical analysis of plasma D-xylose concentration kinetics.

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  • Assessment of small intestinal functional integrity in 172 normal individuals and 9 coeliac disease patients.

    • Main Results:

    • The modified D-xylose test effectively assesses intestinal absorption irrespective of renal and hepatic function.
    • Significantly reduced speed and extent of D-xylose absorption were observed in untreated coeliac disease and during relapse.
    • No significant differences in absorption were found between normal individuals and treated coeliac disease patients.

    Conclusions:

    • The modified D-xylose test is a simple, reliable, and inexpensive method for evaluating intestinal absorption.
    • The test accurately detects impaired small intestinal function, particularly in coeliac disease.
    • This modified test offers a valuable tool for diagnosing malabsorption syndromes.