Related Experiment Video

Updated: Aug 13, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Transient hyperphosphatasaemia of infancy following rotavirus infection

P A Holt, A E Steel, A M Armstrong

    The Journal of Infection
    |November 1, 1984
    PubMed

    Insights

    Transient hyperphosphatasaemia of infancy, a rare condition, was observed in a child following rotavirus infection. This case highlights a potential link between viral illness and this temporary metabolic disorder in infants.

    Area of Science:

    • Pediatrics
    • Biochemistry
    • Virology

    Background:

    • Transient hyperphosphatasaemia of infancy is a rare, self-limiting condition characterized by elevated serum phosphate levels in infants.
    • The etiology of this syndrome is not fully understood, but several triggers have been proposed, including viral infections.

    Observation:

    • This report details a case of transient hyperphosphatasaemia of infancy in a pediatric patient.
    • The onset of hyperphosphatasaemia was noted to coincide with a preceding rotavirus infection.

    Findings:

    • The presented case suggests a potential association between rotavirus infection and the development of transient hyperphosphatasaemia of infancy.
    • A review of existing literature on transient hyperphosphatasaemia of infancy is included to contextualize this observation.

    Implications:

    • This case may prompt further investigation into the role of viral infections, specifically rotavirus, as a trigger for transient hyperphosphatasaemia of infancy.
    • Understanding such associations is crucial for accurate diagnosis and management of metabolic disturbances in infants.

    More Related Videos

    Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators08:01

    Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

    Published on: January 19, 2024

    Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats04:12

    Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

    Published on: March 28, 2025

    Related Concept Videos

    Introduction to Electrolytes01:33

    Introduction to Electrolytes

    In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
    Role of Sodium
    One...
    Roles of Electrolytes: Calcium and Phosphate01:27

    Roles of Electrolytes: Calcium and Phosphate

    Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
    The calcium concentration in blood plasma is primarily regulated...
    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
    Acute Pyelonephritis I: Introduction01:27

    Acute Pyelonephritis I: Introduction

    Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...