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Scaling respiratory pattern and respiratory 'drive'.

D F Boggs, S M Tenney

    Respiration Physiology
    |December 1, 1984
    PubMed
    Summary
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    Pulmonary vascular response of the coati to chronic hypoxia.

    Journal of applied physiology (Bethesda, Md. : 1985)·2000

    In mammals, respiratory timing (TE/TTOT) is constant across species. Respiratory drive, however, increases with body size, indicating adaptation in mammalian respiratory systems.

    Area of Science:

    • Physiology
    • Comparative Biology
    • Respiratory System

    Background:

    • Mammalian respiratory timing and drive are influenced by body size.
    • Previous research suggested interspecific constancy in respiratory timing parameters.

    Purpose of the Study:

    • To test predictions on the relationship between mammalian body size and respiratory drive and timing.
    • To investigate how respiratory timing (TE/TTOT, TI/TTOT) and drive (VT/TI) scale with body mass.
    • To examine the weight-specific respiratory response to hypoxia across mammalian species.

    Main Methods:

    • Measured respiratory timing (TE/TTOT, TI/TTOT) in eleven mammal species (0.033 kg to 520 kg) during quiet breathing.
    • Calculated respiratory drive index (VT/TI) and analyzed its relationship with body mass (BW).

    Related Experiment Videos

  • Assessed the ventilatory response (% delta VI) to hypoxic stimulus (12% O2) and its scaling with BW.

    • Main Results:

    • TE/TTOT was found to be an interspecific constant (0.65 +/- 0.004), while TI/TTOT was 0.345 +/- 0.004.
    • Respiratory drive (VT/TI) scaled with body mass as BW^0.74, closely matching the scaling of basal metabolic rate.
    • Hypoxic ventilatory response scaled with body mass as BW^-0.27.

    Conclusions:

    • Mammalian respiratory timing is conserved across a wide range of body sizes.
    • Respiratory drive increases with body size, suggesting adaptive mechanisms in larger mammals.
    • The observed scaling of hypoxic response suggests differences in respiratory control or muscle properties related to body size.