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Amphetamine-induced taste aversion demonstrated with operant behaviour.

I P Stolerman, G D D'Mello

    Pharmacology, Biochemistry, and Behavior
    |February 1, 1978
    PubMed
    Summary
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    Flavor-amphetamine pairings significantly reduce operant responding in rats, demonstrating a powerful influence on behavior. This effect was observed even after a single pairing, highlighting the strong associative learning between flavors and amphetamine.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Psychopharmacology

    Background:

    • Amphetamine is known to induce taste aversions.
    • The impact of flavor-amphetamine associations on operant behavior remains largely unexplored.

    Purpose of the Study:

    • To investigate the effects of flavor-amphetamine pairings on operant responding in rats.
    • To determine if these pairings influence behavior differently than flavor-saline pairings.

    Main Methods:

    • Rats were trained on a fixed-ratio 40 (FR 40) schedule for water reinforcement.
    • Flavored solutions replaced water, followed by amphetamine or saline injections.
    • Changes in bar-pressing behavior were measured after flavor-amphetamine or flavor-saline pairings.

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    Main Results:

    • A single flavor-amphetamine pairing caused a decrease in responding for that flavor.
    • Three such pairings nearly abolished responding for the associated flavor.
    • Pairing flavors with saline injections did not suppress operant responding.

    Conclusions:

    • Flavor-amphetamine associations exert a potent influence on operant behavior.
    • The observed suppression is specific to the amphetamine-paired flavor, not a general effect.
    • These findings differentiate flavor-amphetamine conditioning from self-administration procedures, independent of response requirements.