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Myoglobin concentration, creatine kinase, and creatine kinase sub-unit B activity in serum after myocardial ischaemia
Scandinavian Journal of Clinical and Laboratory Investigation
|December 1, 1984
Insights
Exercise-induced angina in ischemic heart disease patients did not alter myoglobin or creatine kinase levels. Biomarker concentrations remained unchanged before and after angina episodes during exercise.
Area of Science:
- Cardiology
- Biochemistry
- Exercise Physiology
Background:
- Ischemic heart disease (IHD) poses significant cardiovascular risk.
- Exercise can precipitate angina in IHD patients.
- Biomarkers like myoglobin and creatine kinase are investigated for cardiac injury.
Purpose of the Study:
- To investigate changes in myoglobin and creatine kinase levels during exercise-induced angina in IHD patients.
- To assess the diagnostic utility of these biomarkers in acute cardiac stress.
Main Methods:
- Blood samples were collected from 14 IHD patients.
- Myoglobin concentration and creatine kinase (CK) and creatine kinase sub-unit B (CK-BB) activity were measured.
- Measurements were taken before and after exercise-induced angina pectoris.
Main Results:
- No significant changes were observed in myoglobin concentration.
- Creatine kinase activity remained stable.
- Creatine kinase sub-unit B activity showed no alterations.
Conclusions:
- Myoglobin and creatine kinase are not elevated during exercise-induced angina in IHD patients.
- These biomarkers may not be sensitive indicators of acute myocardial stress in this specific context.
Abstract:
The myoglobin concentration, creatine kinase and creatine kinase sub-unit B activity were estimated in fourteen patients with ischaemic heart disease before and after exercise induced angina pectoris. No changes in these parameters were found.