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Microbial flora associated with pulmonary neoplasms.

R Pieper, K Böök, C E Nord

    Scandinavian Journal of Thoracic and Cardiovascular Surgery
    |January 1, 1984
    PubMed
    Summary
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    Lung tumor microbial flora was investigated in 19 patients. Oropharyngeal bacteria, primarily streptococci and staphylococci, were found in eight patients, suggesting appropriate antibiotic prophylaxis.

    Area of Science:

    • Medical Microbiology
    • Oncology
    • Pulmonology

    Background:

    • The lung microbiome's role in tumor development and progression is an emerging area of research.
    • Understanding the microbial flora associated with lung tumors is crucial for developing targeted therapeutic strategies.
    • Oropharyngeal bacteria have been implicated in various systemic infections and inflammatory conditions.

    Purpose of the Study:

    • To investigate the microbial flora present in lung tumor biopsy specimens.
    • To identify the origin and predominant microorganisms associated with lung tumors.
    • To inform the selection of appropriate prophylactic antibiotic regimens for patients undergoing lung tumor surgery.

    Main Methods:

    • Biopsy specimens from resected bronchus and peripheral lung tissue were collected from 19 patients with lung tumors.

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  • Cultures for aerobic and anaerobic microorganisms were performed prior to antibiotic administration.
  • Microbial identification focused on determining the predominant bacterial and fungal species.

    • Main Results:

    • Microbial growth was obtained in eight of the 19 patients (42.1%).
    • The identified microflora was predominantly of oropharyngeal origin, with *Streptococcus* and *Staphylococcus* species being the most common isolates.
    • Fungal growth (*Candida parapsilosis*) was observed in one patient.
    • Eleven patients (57.9%) yielded negative cultures.

    Conclusions:

    • The study suggests that lung tumors can harbor microbial flora, often originating from the oropharynx.
    • Prophylactic antibiotic regimens targeting streptococci and staphylococci appear appropriate for patients with lung tumors.
    • Further research is warranted to elucidate the clinical significance of the lung tumor microbiome.