An experimental study of different contrast media in the epidural space

In the experimental study of different contrast media, metrizamide has been found to be very safe for epidurography as no clinical, radiologic, or histologic changes after epidural injection were seen. Next in order was meglumine iothalmate. However, sodium containing salts like sodium acetrazoate and sodium iothalmate were found to be very irritating to the nerve roots and the spinal cord and, therefore, should not be used for epidurographic studies.