Jove
Visualize
Contact Us

Related Experiment Videos

Hyperuricaemia in sickle cell disease.

U P Isichei

    Tropical and Geographical Medicine
    |December 1, 1984
    PubMed
    Summary

    Children with sickle cell disease have significantly higher serum uric acid levels compared to healthy peers. This finding suggests potential health implications requiring further investigation in pediatric patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria.

    The Indian journal of medical research·2007
    Same author

    Neonatal chemical hypothyroidism in Nigeria.

    Annals of tropical paediatrics·2004
    Same author

    Iodine deficiency disorders in pre-adolescent and adolescent children in Nigeria, West Africa.

    West African journal of medicine·1998
    Same author

    The role of ions in goitre prevalence in two local government areas of Plateau State, Nigeria.

    West African journal of medicine·1996
    Same author

    Endemic goiter in the Jos Plateau region of northern Nigeria.

    Endocrine journal·1995
    Same author

    Thyroid function profile and differential serum lipid and lipoproteins in Africans with endemic goitre.

    African journal of medicine and medical sciences·1994
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Pediatric Hematology
    • Biochemistry
    • Clinical Chemistry

    Background:

    • Sickle cell disease (SCD) is a genetic blood disorder.
    • Hyperuricemia, or high uric acid levels, is a known complication in some chronic diseases.
    • The relationship between SCD and uric acid levels in children requires further elucidation.

    Purpose of the Study:

    • To determine serum uric acid levels in children with homozygous sickle cell disease.
    • To compare these levels with those of a healthy pediatric control group.
    • To discuss the implications of observed uric acid level differences.

    Main Methods:

    • Serum uric acid levels were measured using the uricase method.
    • The study included 69 children under 11 years with homozygous sickle cell disease.
    • A control group of healthy children in the same age range was used for comparison.

    Main Results:

    • A statistically significant difference in mean serum uric acid levels was observed between the groups.
    • 28% of children with sickle cell disease had uric acid levels exceeding the upper normal limit of controls.
    • This indicates a higher prevalence of elevated uric acid in pediatric SCD patients.

    Conclusions:

    • Children with homozygous sickle cell disease exhibit significantly higher serum uric acid levels.
    • Elevated uric acid may be a notable biochemical finding in pediatric SCD.
    • The clinical implications of these findings warrant further investigation and discussion.

    Related Experiment Videos