[Behavior of conjugated bile acids in chronic liver disease]

In 24 persons with healthy liver and 44 patients with chronic hepatopathies of different degree of severity (23 women and 16 men with chronic active hepatitis as well as 4 women and 1 man with unspecific degenerative damage of the liver parenchyma) in the C-bile conjugated bile acids were qualitatively differentiated. In contrast to persons with healthy liver in chronic hepatopathies apart from conjugated bile acids free bile acids appeared. The conjugation of the bile acids with taurine was proved in greater frequency than the glycine conjugation. Parallel to the degree of severity of the hepatopathy particularly the proportion of the taurine-conjugated dihydroxycholan acids increased, among which the tauro-chenodesoxycholic acid prevailed. The conjugation of the bile acids with glycine also in chronic hepatopathies remained longest in the fraction of the trihydroxycholan acids. The examinations show that the qualitative proof of the conjugated bile acids in the bile gives an additional information for the diagnostic estimation of the chronic hepatopathies.