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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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[Hemodynamics in ischemia: diastolic phase]

I Amende, R Simon, W P Hood

    Zeitschrift Fur Kardiologie
    |January 1, 1984
    PubMed

    Insights

    Acute ischemia impairs diastolic function by slowing ventricular relaxation and delaying filling. This impacts the heart

    Area of Science:

    • Cardiology
    • Physiology
    • Biochemistry

    Context:

    • The cardiac cycle's diastolic phase involves complex relaxation and filling processes.
    • Left ventricular diastolic function depends on intrinsic myocardial properties and extrinsic factors.
    • Diastole is crucial for adequate cardiac output and myocardial perfusion.

    Purpose:

    • To elucidate the mechanisms by which acute ischemia affects left ventricular diastolic function.
    • To detail the physiological alterations in diastolic phases due to ischemia.
    • To describe the measurable parameters indicating impaired diastolic function.

    Summary:

    • Diastole comprises isovolumic relaxation, rapid and slow filling, and atrial contraction.
    • Ischemia disrupts diastolic function by slowing isovolumic relaxation and delaying ventricular filling.
    • Key indicators of impaired diastolic function include reduced peak negative dP/dt, increased time constant (T), and altered filling rates.

    Impact:

    • Understanding ischemic effects on diastolic function is vital for diagnosing and managing cardiac conditions.
    • Identifies specific physiological changes that can be monitored non-invasively.
    • Highlights the energy-dependent nature of myocardial relaxation and its vulnerability to ischemia.

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