[Action of baliz on the ultrastructure and toxin formation of Staphylococcus aureus]

The effect of the antibacterial preparation Balysum on the ultrastructure of S. aureus, as well as on the process of the formation of alpha-toxin and the secretion of plasmacoagulase in this organism, has been studied. Balysum at a concentration of 8% (as used in clinical practice) has been found to induce changes in the ultrastructure of S. aureus as early as within the first 10 minutes. The maximum effect of the preparation is manifested in 60 minutes. At an early period of incubation damages occur in the cell-surface structures and, to a certain extent, in the membrane-ribosomal apparatus. The increased time of incubation leads to more profound changes in these structures and even to the death of the cell. In a highly toxic strain of S. aureus Balysum has proved to decrease the formation of alpha-toxin 4 times, while having no effect on the results of the plasma coagulation test.