[Immunohormonal homeostasis in meningococcal meningitis]

The examination of 18 patients with meningococcal infection has revealed the presence of reciprocal relationships between changes in the content of cortisol and triiodothyronine in their blood, especially at the beginning of the disease. The dynamics of changes in the concentration of rosette-forming cells has proved to be similar to that of changes in the concentration of triiodothyronine. A decrease in the level of thyroid hormones in the blood has been observed in experimental infections and oncological processes in mice, rats or guinea pigs, as well as after the injection of adjuvants into these animals. The centroid factor analysis with the use of the criteria of symmetry and asymmetry has revealed 3 main factors in the process under study, interpreted as follows: the homeostasis destabilization factor of infectious nature (F1), the homeostasis maintenance and restoration factor of endogenous nature (F2) and the factor of the integral relationship catabolism/anabolism between energy streams in the body (F3).