IgE antibody studies in a case of generalized allergic reaction to human insulin

A patient developed a generalized reaction to purified bovine, purified porcine and human insulin. High levels of IgE antibody to bovine, porcine, human emp and human crb insulin were demonstrated. These fell dramatically following desensitization with human crb insulin. All four types of insulin gave superimposable RAST inhibition curves indicating a common allergen determinant.