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[Comparative double-blind study: alizapride-metoclopramide].

F Oberling

    Annales De Gastroenterologie Et D'Hepatologie
    |January 1, 1984
    PubMed
    Summary
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    Alizapride demonstrated superior anti-emetic efficacy compared to metoclopramide in patients undergoing chemotherapy. This study highlights alizapride as a more effective option for managing chemotherapy-induced nausea and vomiting.

    Area of Science:

    • Oncology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Chemotherapy often induces nausea and vomiting.
    • Anti-emetic drugs are crucial for patient supportive care.
    • Metoclopramide is a commonly used anti-emetic.

    Purpose of the Study:

    • To compare the anti-emetic efficacy of alizapride and metoclopramide.
    • To evaluate drug effectiveness in patients receiving anti-mitotic chemotherapy.

    Main Methods:

    • A double-blind study involving 21 patients.
    • Patients received either alizapride (50 mg) or metoclopramide (10 mg) in ampoules.
    • Administration occurred before and after chemotherapy sessions.

    Main Results:

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    • Alizapride achieved 24 good/excellent results and 4 nil results.
    • Metoclopramide achieved 16 good/excellent results and 13 nil results.
    • Alizapride showed statistically significant superiority (p < 0.05).

    Conclusions:

    • Alizapride is more effective than metoclopramide in preventing chemotherapy-induced emesis.
    • Alizapride represents a significant advancement in anti-emetic therapy for cancer patients.