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[Intramuscular premedication with diazepam in a fat emulsion]
Cahiers D'Anesthesiologie
|May 1, 1984
Summary
Intramuscular diazepam in fat emulsion provided effective sedation for patients, with reduced injection site pain compared to other formulations. Plasma concentrations and sedation levels remained comparable.
Area of Science:
- Pharmacology
- Anesthesiology
- Clinical Pharmacy
Context:
- Premedication is crucial for patient comfort and procedural success.
- Intramuscular injections are common routes for drug administration.
- Evaluating novel drug formulations for improved patient experience is essential.
Purpose:
- To assess the efficacy and tolerability of diazepam in a fat emulsion for intramuscular premedication.
- To compare patient-reported pain and sedation levels with diazepam in fat emulsion versus diazepam in propylene glycol.
Summary:
- 106 patients received 10 mg of diazepam in a fat emulsion intramuscularly for premedication.
- Sedation was achieved in 53% of patients, with 33% feeling apprehensive and 14% anxious.
- Pain at the injection site was reported by only 4 patients, and plasma diazepam concentration at induction was 130 ng/ml.
Impact:
- Diazepam in fat emulsion offers a potentially more tolerable alternative for intramuscular premedication.
- This formulation may improve patient compliance and reduce procedural anxiety.
- Further research could explore optimal dosing and patient selection for this formulation.