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Human Monotard insulin: dose-dependent subcutaneous absorption.

P Hildebrandt, K Birch, L Sestoft

    Diabetes Research (Edinburgh, Scotland)
    |November 1, 1984
    PubMed
    Summary
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    Higher doses of Monotard HM (semisynthetic human Lente-type insulin) show slower subcutaneous absorption in patients with insulin-dependent diabetes mellitus (IDDM). This study found that increasing insulin dose significantly decreased absorption rates.

    Area of Science:

    • Pharmacokinetics
    • Endocrinology
    • Diabetes Mellitus Research

    Background:

    • Subcutaneous absorption of insulin is crucial for glycemic control in insulin-dependent diabetes mellitus (IDDM).
    • Understanding dose-dependent absorption characteristics of specific insulin formulations is essential for optimizing therapy.

    Purpose of the Study:

    • To investigate the impact of varying doses of semisynthetic human Lente-type insulin (Monotard HM) on its subcutaneous absorption in IDDM patients.
    • To quantify the relationship between insulin dose and absorption rate.

    Main Methods:

    • Radioactive iodine (125-I) labeled Monotard HM was administered subcutaneously in doses of 6, 12, 24, and 36 IU to 9 IDDM patients on consecutive days.
    • Residual radioactivity at injection sites was measured over 49 hours to assess insulin absorption.

    Related Experiment Videos

  • Time for 50% of initial activity to disappear was calculated for each dose.

    • Main Results:

    • A significant dose-dependent decrease in subcutaneous absorption rates was observed with increasing Monotard HM doses.
    • The time for 50% of initial activity to disappear increased with dose: 9.0 hr (6 IU), 8.9 hr (12 IU), 10.9 hr (24 IU), and 14.8 hr (36 IU).

    Conclusions:

    • Subcutaneous absorption of Monotard HM is dose-dependent, with higher doses exhibiting slower absorption kinetics.
    • These findings have implications for insulin regimen adjustments in IDDM management to achieve desired pharmacokinetic profiles.