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[The dexamethasone suppression test in agoraphobia with panic attacks. 30 cases].

J Cottraux, B Claustrat

|January 1, 1984

Summary

Agoraphobia with panic attacks may stem from different causes. Some cases show links to major depressive disorders, suggesting a connection beyond typical anxiety states.

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Area of Science:

Psychiatry
Neuroendocrinology

Background:

Agoraphobia with panic attacks is a common condition.
The dexamethasone suppression test (DST) is used to assess hypothalamic-pituitary-adrenal (HPA) axis function.

Observation:

Six out of 30 agoraphobic subjects with panic attacks had abnormal DST results.
Non-suppressor patients showed a trend towards higher rates of major depressive disorders.

Findings:

Abnormal DST results in some agoraphobic patients suggest HPA axis dysregulation.
A higher prevalence of major depressive disorders and family history of depression in non-suppressors indicates a potential subtype.

Implications:

Agoraphobia with panic attacks may be a heterogeneous disorder, not solely an anxiety state.
Some agoraphobia presentations might be more closely related to endogenous depression, warranting different diagnostic and treatment approaches.

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