Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflex modification as an objective test for sensory processing following toxicant exposure.

J R Ison

    Neurobehavioral Toxicology and Teratology
    |November 1, 1984
    PubMed
    Summary

    Assessing toxic exposure effects requires evaluating sensory function. A novel reflex inhibition method offers a rapid, objective, and sensitive approach for both human and animal toxicology studies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Loss of prestin does not alter the development of auditory cortical dendritic spines.

    Neural plasticity·2011
    Same author

    Scopolamine reduces sensitivity to auditory gaps in the rat, suggesting a cholinergic contribution to temporal acuity.

    Hearing research·2000
    Same author

    A behavioral study of temporal processing and visual persistence in young and aged rats.

    Behavioral neuroscience·1998
    Same author

    The effect of spatial separation of signal and noise on masking in the free field as a function of signal frequency and age in the mouse.

    The Journal of the Acoustical Society of America·1998
    Same author

    Changes in temporal acuity with age and with hearing impairment in the mouse: a study of the acoustic startle reflex and its inhibition by brief decrements in noise level.

    The Journal of the Acoustical Society of America·1998
    Same author

    Facilitation and inhibition of the acoustic startle reflex in the rat after a momentary increase in background noise level.

    Behavioral neuroscience·1998

    Area of Science:

    • Neuroscience
    • Toxicology
    • Behavioral Science

    Background:

    • Psychological function assessment post-toxic exposure necessitates sensory process evaluation.
    • Sensory function is crucial for interpreting behavioral test results and has well-established principles.
    • Comparative sensory system structures facilitate cross-species extrapolation of toxic effects.

    Purpose of the Study:

    • To introduce an objective method for assessing stimulus detection in toxicological studies.
    • To detail parameters and sensitivity of reflex inhibition as a measure of sensory function.
    • To demonstrate the impact of sensory dysfunction on reflex inhibition.

    Main Methods:

    • Utilized reflex inhibition by irrelevant stimuli as an objective measure of stimulus detection.
    • Detailed two basic parameters of reflex inhibition across several species.
    • Investigated sensitivity to near-threshold stimuli and effects of sensory dysfunction.

    Main Results:

    • Demonstrated reflex inhibition's utility in assessing sensory function.
    • Highlighted the method's sensitivity to near-threshold stimuli.
    • Showcased the impact of sensory dysfunction on reflex inhibition patterns.

    Conclusions:

    • Reflex inhibition offers a rapid, objective, and sensitive measure for sensory function in toxicology.
    • The method is suitable for both human and animal studies, aiding in cross-species extrapolation.
    • This approach enhances the interpretation of behavioral and psychological assessments following toxic exposure.

    Related Experiment Videos