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Related Experiment Videos

Dopamine receptor elevation by cholecystokinin.

A Dumbrille-Ross, P Seeman

    Peptides
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Cholecystokinin (CCK) significantly increases dopamine D2 receptors in rat brain regions, particularly the nucleus accumbens. This peptide acts as a potential physiological modulator of the brain's dopaminergic system.

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    Area of Science:

    • Neuroscience
    • Neuropharmacology
    • Peptide Signaling

    Background:

    • High cholecystokinin (CCK) concentrations in brain areas like the striatum suggest a role in modulating dopaminergic transmission.
    • The interaction between CCK and dopamine receptors is crucial for understanding brain function.

    Purpose of the Study:

    • To investigate the effect of cholecystokinin (CCK) on dopamine D2 receptors in the rat striatum and nucleus accumbens.
    • To determine if CCK influences dopamine D2 receptor density in vitro and in vivo through central and peripheral administration.

    Main Methods:

    • Utilized 3H-spiperone binding assays to quantify dopamine D2 receptor density (Bmax).
    • Administered CCK in vitro, via continuous intraventricular infusion, and single intraperitoneal injections.

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  • Compared CCK effects with neurotensin infusion to confirm specificity.

    • Main Results:

    • In vitro incubation with CCK increased D2 receptor density by 20% in the nucleus accumbens.
    • Continuous intraventricular CCK infusion elevated D2 receptors by ~40% in the accumbens and ~25% in the striatum.
    • Single IP injections of CCK or caerulein increased D2 receptors by 15-20% in both regions, with effects lasting up to 14 days.

    Conclusions:

    • Cholecystokinin (CCK) administration elevates dopamine D2 receptor density in the rat accumbens and striatum.
    • CCK demonstrates potential as a physiological modulator of the central dopaminergic system.
    • The observed increase in D2 receptor density is specific to CCK and can be long-lasting.