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Difference between the thyroid gland of normal and hypomyelinated jimpy mice--a light microscopic study
Proceedings of the National Science Council, Republic of China. Part B, Life Sciences
|January 1, 1984
Summary
Jimpy mice exhibit fewer thyroid follicles and more capillaries per cell, leading to hypothyroidism and hypomyelination. This study details thyroid gland structural differences in jimpy mice.
Area of Science:
- Histology
- Endocrinology
- Neurobiology
Background:
- The jimpy mouse is a model for X-linked hypomyelination.
- Thyroid hormone is crucial for myelination during development.
Purpose of the Study:
- To compare the thyroid gland structure in normal and jimpy mice.
- To investigate the morphological basis of hypothyroidism in jimpy mice.
Main Methods:
- Light microscopic quantitative analysis of thyroid glands from normal and jimpy male mice.
Main Results:
- Jimpy mice have fewer, smaller thyroid follicles with columnar cells and more intraepithelial capillaries compared to normal mice.
- The ratio of intraepithelial capillaries to follicular cells is significantly higher in jimpy mice.
- S-follicles (ultimobranchial cysts) are well-developed in jimpy mice.
Conclusions:
- Thyroid follicular cells in jimpy mice show increased activity, but reduced follicle number leads to hypothyroidism.
- Hypothyroidism in jimpy mice contributes to their hypomyelination phenotype.