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Related Experiment Videos

[Endogenous creatinine clearing during cytostatic therapy].

F Sterz, J Borkenstein, H Samonigg

    Wiener Medizinische Wochenschrift (1946)
    |November 30, 1984
    PubMed
    Summary

    Cytostatic treatment impacts kidney function differently based on patient reactions. While some patients show impairment due to side effects like diarrhea, others experience improved kidney function, suggesting personalized hydration strategies are crucial.

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    Neurocritical care·2015

    Area of Science:

    • Nephrology
    • Oncology
    • Pharmacology

    Context:

    • Assessing kidney function in cancer patients undergoing cytostatic therapy.
    • Evaluating the impact of cytostatic agents on renal parameters.
    • Investigating patient-specific responses to chemotherapy.

    Purpose:

    • To determine the effect of cytostatic treatment on endogenous creatinine clearance.
    • To correlate specific side effects and patient reactions with changes in kidney function.
    • To evaluate the necessity and potential risks of general hyperhydration during cytostatic therapy.

    Summary:

    • Twenty-five patients with malignant neoplasia received cytostatic treatment, with kidney function monitored via endogenous creatinine clearance.
    • Patients experiencing hyperemesis and diarrhea showed impaired kidney function, whereas those with hyperkinetic reactions exhibited improved function.

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  • No significant changes in kidney function were observed in patients without immediate side effects.

    • Impact:

    • Findings suggest that routine hyperhydration during cytostatic treatment may not be beneficial and could be detrimental, particularly for patients with hyperkinetic reactions.
    • Highlights the importance of individualized patient monitoring and management during chemotherapy.
    • Informs clinical decisions regarding fluid management in oncology patients receiving cytostatic agents.