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Immediate type hypersensitivity in murine coccidiosis
Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
|December 1, 1984
Summary
Mice infected with Eimeria falciformis developed an immediate hypersensitivity reaction, indicated by footpad swelling, starting ten days post-infection. This immune response was transferable via serum, suggesting antibody involvement in Eimeria falciformis immunity.
Area of Science:
- Immunology
- Parasitology
- Veterinary Medicine
Background:
- Eimeria falciformis is a protozoan parasite causing coccidiosis in rodents.
- Understanding the host immune response to Eimeria falciformis is crucial for developing effective control strategies.
Purpose of the Study:
- To investigate the development of immediate type hypersensitivity in mice infected with Eimeria falciformis.
- To characterize the kinetics and transferability of this hypersensitivity reaction.
Main Methods:
- Subcutaneous injection of soluble merozoite antigen into the footpad of infected mice.
- Measurement of footpad swelling (FPS) as an indicator of hypersensitivity.
- Assessment of reaction transferability using immune serum.
Main Results:
- An immediate type hypersensitivity reaction, measured by footpad swelling, was observed in mice infected with Eimeria falciformis.
- The reaction became detectable ten days post-infection, peaked around day 13, and subsequently declined.
- Neither increased oocyst dose nor infection number enhanced the footpad swelling response.
- The hypersensitivity was transferable to naive recipients via immune serum, indicating an antibody-mediated mechanism.
Conclusions:
- Mice infected with Eimeria falciformis develop a measurable immediate type hypersensitivity.
- The immune response is antibody-dependent and develops after a specific incubation period post-infection.
- This finding contributes to understanding the immunopathology of Eimeria falciformis infections.