Possible origin of amniotic fluid constituents influencing fibrinolytic activity

An attempt was made to clarify the origin of the amniotic fluid constituents affecting fibrinolysis. For this purpose, saline extracts were prepared from various extra-fetal gestational tissues (EGT) as well as from various fetal excretory products (FEP) and their effect on an euglobinolytic system was studied in vitro. It was found that extracts from FEPs stimulated, whereas those from EGTs inhibited fibrinolysis. It is concluded that the fibrinolysis inhibiting amniotic fluid constituents originate from the placenta and the fetal membranes, whereas the fibrinolysis stimulating ones from various sources of fetal origin.