Metabolism of nitrosamines by cytochrome P-450 isozymes

Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.