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Blood cell effects in membrane plasma separation.

P S Malchesky, J Wojcicki, M Moorman

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1984
    PubMed
    Summary
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    Blood cell and membrane properties significantly impact plasma separation rates and red blood cell lysis. Membrane pore size and surface structure are key factors influencing hemolysis during filtration processes.

    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Fluid Dynamics

    Background:

    • Blood cell and membrane properties are critical for understanding hemolysis and cell deposition.
    • These factors directly influence maximum plasma separation rates in filtration systems.
    • Previous studies have established the general importance of these properties.

    Purpose of the Study:

    • To correlate red blood cell lysis with membrane properties.
    • To investigate the role of interfacial surface tension and shear rate in cell deformation.
    • To improve theoretical models for plasma separation by including blood and membrane characteristics.

    Main Methods:

    • Utilized Scanning Electron Microscopy (SEM) for membrane surface analysis.
    • Employed a filtration model that incorporates red blood cell deformability.

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  • Measured mean membrane pore size and correlated it with hemolysis data.
  • Determined interfacial surface tension as a function of shear rate.

    • Main Results:

    • Membranes with larger mean pore sizes showed hemolysis at lower transmembrane pressures.
    • Membrane surface structure was found to be more critical than pore tortuosity for hollow fiber membranes.
    • A high correlation was found between interfacial surface tension and shear rate (up to 1000s-1).
    • Interfacial surface tensions were below 6 dynes/cm at high shear rates.

    Conclusions:

    • Mean membrane pore data and SEM observations effectively correlate red blood cell lysis with membrane properties.
    • Including blood and membrane properties in plasma separation analysis significantly improves the fit of experimental data to theoretical models.
    • Cell deformability and interfacial surface tension are crucial parameters in high shear rate filtration.