Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hypoxic response to hypovolemia.

H Metzger, S Heuber-Metzger

    Advances in Experimental Medicine and Biology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Hypovolemic hypotension significantly reduces tissue oxygen in the brain cortex and liver. This decrease is exacerbated by lower body temperatures, leading to irreversible liver damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    IUIS council meets.

    Immunology today·2014
    Same author

    Vaccines and infectious disease.

    Immunology today·2014
    Same author

    [Symptom-oriented follow-up of early breast cancer compared to intensive surveillance. Results of a prospective multicentre study: update and 10-year overall survival].

    Deutsche medizinische Wochenschrift (1946)·2012
    Same author

    A case of posterior myocardial infarction started with paroxysmal ventricular tachycardia followed by various rhythms with prolonged survival.

    Archives des maladies du coeur et des vaisseaux·2010
    Same author

    Fatal poisoning by digitalis associated with dial.

    Archives des maladies du coeur et des vaisseaux·2010
    Same author

    [Selective pre- intra- and postoperative bile duct diagnosis--an efficient and low complication regimen within the scope of laparoscopic cholecystectomy. Early and late results of a prospective study].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2001

    Area of Science:

    • Physiology
    • Cardiovascular Research
    • Hypoxia Studies

    Background:

    • Hypovolemic hypotension poses a critical threat to tissue oxygenation.
    • Understanding organ-specific responses to reduced blood volume is crucial for clinical management.

    Purpose of the Study:

    • To investigate the impact of hypovolemic hypotension on tissue partial pressure of oxygen (PO2) in the rat brain cortex and liver.
    • To determine the influence of body temperature on tissue PO2 during hypovolemia.

    Main Methods:

    • Utilized needle and surface PO2 electrodes to measure tissue oxygen levels in rat brain cortex and liver surface.
    • Induced controlled hypovolemic hypotension and monitored mean arterial pressure (MAP).
    • Assessed tissue PO2 at different body temperatures and after retransfusion.

    Related Experiment Videos

    Main Results:

    • Cerebral cortex PO2 significantly decreased from 34 +/- 18 mm Hg to 24 +/- 16 mm Hg during hypotension (MAP 35-40 mm Hg).
    • Tissue PO2 reduction was more pronounced at lower body temperatures (32-34°C) compared to slightly elevated temperatures (37.5-39°C).
    • Extensive anoxic regions and signs of irreversible liver damage were observed after 90 minutes of hypovolemia, with significantly lower post-retransfusion PO2.

    Conclusions:

    • Sympathico-adrenergic vasoconstriction in hypovolemic hypotension prioritizes cerebral blood flow but is insufficient to maintain adequate brain tissue oxygenation.
    • Hypovolemia-induced hypoxia significantly impacts the liver, potentially causing irreversible damage.
    • Body temperature is a critical factor modulating the severity of tissue hypoxia during hypovolemic hypotension.