Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A two-sample censored-data rank test for acceleration.

N E Breslow, L Edler, J Berger

    Biometrics
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Co-expression of mutated and normal adrenoleukodystrophy protein reduces protein function: implications for gene therapy of X-linked adrenoleukodystrophy.

    Human molecular genetics·2000
    Same author

    Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation.

    The EMBO journal·2000
    Same author

    A randomized comparison of balloon angioplasty versus rotational atherectomy in complex coronary lesions (COBRA study).

    European heart journal·2000
    Same author

    Treatment of aortocoronary vein graft lesions with membrane-covered stents: A multicenter surveillance trial.

    Circulation·2000
    Same author

    The law of unintended consequences in action: increase in incidence of hypokalemia with improved adequacy of dialysis.

    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis·2000
    Same author

    Schistosoma mansoni: adhesion of mannan-binding lectin to surface glycoproteins of cercariae and adult worms.

    Experimental parasitology·2000

    A new score test complements the logrank test for survival data, offering better power against crossing hazards. This method shows comparable small-sample performance to existing survival analysis tests.

    Area of Science:

    • Biostatistics
    • Survival Analysis
    • Statistical Hypothesis Testing

    Background:

    • Comparing censored survival curves is crucial in medical research.
    • The logrank test is a standard method but has limitations with non-proportional hazards.
    • Existing methods may lack power when hazard functions cross.

    Purpose of the Study:

    • To propose a novel score test as an alternative to the logrank test.
    • To evaluate the test's performance against rank-regression alternatives.
    • To assess the test's power against acceleration (crossing hazards) alternatives.

    Main Methods:

    • Development of a score test statistic for proportional hazards.
    • Asymptotic distribution analysis of the test statistic.

    Related Experiment Videos

  • Monte Carlo simulations to compare small-sample properties with logrank and ranksum tests.

    • Main Results:

    • The proposed score test statistic follows an asymptotic normal distribution.
    • The test demonstrates good power against acceleration alternatives where logrank tests fail.
    • Small-sample properties are comparable to established logrank and ranksum procedures.

    Conclusions:

    • The score test is a valuable complement to the logrank test for survival data analysis.
    • It provides a robust alternative when proportional hazards are violated, particularly with crossing hazards.
    • The test offers reliable performance in small samples.