Related Experiment Video
Updated: Aug 12, 2026

T Cells Capture Bacteria by Transinfection from Dendritic Cells
Published on: January 13, 2016
Abstract:
The ability of mouse lymphocytes to transform in a serum-free medium in response to Concanavalin A was found to depend upon the presence of transferrin. Iron chelates were ineffective, as also were monoferric transferrin fragments, but both homologous and heterologous transferrins promoted transformation. Optimal transformation occurred with 10-50 micrograms/ml of transferrin, and at 30-70 per cent iron saturation. Transferrin was bound by the transforming cells, and subsequently released without degradation following the delivery of iron. Iron uptake preceded DNA synthesis. Iron chelates, despite their inability to promote transformation, could also deliver iron to lymphocytes. It is postulated that transferrin may fulfil functions additional to that of supplying iron.
More Related Videos
Related Concept Videos
The Early Endosome: Endocytosis of Transferrin
Cells of the Adaptive Immune Response
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

