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[Pulmonary volume and flows in asthmatic children in therapy with prompt and delayed-action theophylline: preliminary

A Fiocchi, P Berardinelli, C Di Donna

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |September 1, 1984
    PubMed

    Insights

    Plain theophylline showed better results than sustained-release (SR) theophylline in improving lung function in asthmatic children. Further studies are needed to confirm SR theophylline

    Area of Science:

    • Pediatric Pulmonology
    • Pharmacology
    • Respiratory Medicine

    Context:

    • Asthma management in children requires effective long-term therapies.
    • Theophylline is a bronchodilator used for asthma prophylaxis.
    • Sustained-release (SR) theophylline formulations aim for improved compliance and efficacy.

    Purpose:

    • To compare the efficacy of plain theophylline versus SR theophylline in pediatric asthma.
    • To evaluate the impact of these theophylline formulations on pulmonary function tests.
    • To assess bronchodilator response after Albuterol inhalation.

    Summary:

    • A study involving 12 asthmatic children compared plain theophylline, SR theophylline, and no therapy.
    • Pulmonary function (statics, dynamics, and flow-volume curves) was assessed using body plethysmography before and after Albuterol inhalation.
    • Plain theophylline demonstrated superior effects on static lung volumes (TV, RV, FRC) and dynamic parameters (MMEF, V 0.50 TV) compared to SR theophylline.

    Impact:

    • Findings suggest plain theophylline may be more effective than current SR formulations for children's asthma.
    • Highlights the need for further pharmacokinetic, clinical, and spirometric research.
    • Informs potential therapeutic strategies for long-term asthma control in pediatric populations.

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