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Related Experiment Videos

Episodic angioedema associated with eosinophilia.

G J Gleich, A L Schroeter, J P Marcoux

    Transactions of the Association of American Physicians
    |January 1, 1984
    PubMed
    Summary

    This study describes a rare syndrome of recurrent angioedema, urticaria, and fever characterized by high eosinophil counts. Glucocorticoid therapy effectively managed symptoms, indicating a benign and distinct clinical entity.

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    Area of Science:

    • Internal Medicine
    • Allergy and Immunology
    • Hematology

    Background:

    • Recurrent angioedema, urticaria, and fever can indicate complex underlying conditions.
    • Distinguishing rare syndromes is crucial for appropriate patient management.

    Observation:

    • Four patients presented with recurrent angioedema, urticaria, and fever.
    • Attacks were associated with significant weight gain (up to 18%) and marked eosinophilia (leukocyte counts up to 108,000/microliters with 88% eosinophils).

    Findings:

    • Glucocorticoid therapy resulted in symptom resolution, including reduced fever, diuresis, and normalization of leukocyte and eosinophil counts.
    • Treatment varied from intermittent prednisone in children to alternate-day administration or no treatment in adults.
    • Long-term follow-up (2-17 years) revealed no cardiac involvement or threat to vital organ function.

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    Implications:

    • The syndrome appears to be a distinct entity, separate from hypereosinophilic syndrome, due to its unique characteristics and benign prognosis.
    • This condition, despite its severity during attacks, does not typically lead to long-term organ damage.
    • Understanding this syndrome aids in accurate diagnosis and management, differentiating it from other eosinophilic disorders.