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Related Experiment Videos

Ophthalmic ointments.

J S Robin, P P Ellis

    Survey of Ophthalmology
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Ophthalmic ointments offer enhanced ocular contact time for topical drug delivery, improving antibiotic efficacy. However, corticosteroid ointments show poorer ocular penetration compared to suspensions, potentially due to drug-base interactions.

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    Area of Science:

    • Ophthalmology
    • Pharmaceutics
    • Drug Delivery

    Background:

    • Ointments are utilized as ocular drug vehicles in topical therapy.
    • They offer good tolerability, safety, and prolonged ocular contact time.
    • This enhanced contact can improve ocular drug levels, particularly for antibiotics.

    Purpose of the Study:

    • To evaluate the efficacy and penetration of ophthalmic ointments as ocular drug vehicles.
    • To compare the ocular penetration of corticosteroid ointments with suspension preparations.
    • To assess the safety and effectiveness of ophthalmic ointments in specific ocular conditions.

    Main Methods:

    • Experimental investigation of ocular drug penetration.
    • Comparison of ointment vehicle versus suspension vehicle for drug delivery.

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  • Assessment of drug-vehicle interactions and compound-specific effects.

    • Main Results:

    • Ointments provide enhanced ocular contact time, beneficial for certain antibiotics.
    • Corticosteroid ointments demonstrate less ocular penetration than suspension preparations.
    • Drug binding to the ointment base and specific steroid compounds may influence penetration.

    Conclusions:

    • Ophthalmic ointments are effective for ocular drug delivery, especially for antibiotics.
    • Ointment penetration can be limited for corticosteroids, necessitating further research into formulation and compound selection.
    • Ophthalmic ointments are safe and effective for use in eyes with secure wound closure post-surgery, but should be avoided in eyes with open wounds.