Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic acetazolamide intoxication.

W A Watson, J C Garrelts, P D Zinn

    Journal of Toxicology. Clinical Toxicology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Epidemiology and control of Aujeszky's disease.

    Revue scientifique et technique (International Office of Epizootics)·2020
    Same author

    Influence of Temperature and Wetting Period on Inoculum Production by Monilinia fructicola in Peach Twig Cankers.

    Plant disease·2019
    Same author

    Resolution of acyclovir-associated neurotoxicity with the aid of improved clearance estimates using a Bayesian approach: A case report and review of the literature.

    Journal of clinical pharmacy and therapeutics·2017
    Same author

    The outcome of North American pediatric unintentional mushroom ingestions with various decontamination treatments: an analysis of 14 years of TESS data.

    Toxicon : official journal of the International Society on Toxinology·2009
    Same author

    Antithyroid drug regimen for treating Graves' hyperthyroidism.

    The Cochrane database of systematic reviews·2005
    Same author

    Antithyroid drug regimen for treating Graves' hyperthyroidism.

    The Cochrane database of systematic reviews·2004
    Same journal

    Ingestion of high-dose buprenorphine by a 4 year-old child.

    Journal of toxicology. Clinical toxicology·2005
    Same journal

    A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

    Journal of toxicology. Clinical toxicology·2005
    Same journal

    Methamphetamine toxicity secondary to intravaginal body stuffing.

    Journal of toxicology. Clinical toxicology·2005
    Same journal

    Duodenal perforation after ibuprofen overdose.

    Journal of toxicology. Clinical toxicology·2005
    Same journal

    Delayed dystonia following pimozide overdose in a child.

    Journal of toxicology. Clinical toxicology·2005
    Same journal

    Pattern of acute poisonings in Mashhad, Iran 1993-2000.

    Journal of toxicology. Clinical toxicology·2005
    See all related articles

    Severe acidosis from acetazolamide is rare. This case report details a patient with significantly elevated acetazolamide levels and prolonged half-life, highlighting the importance of monitoring drug concentrations in patients with impaired renal function.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Ophthalmology

    Background:

    • Acetazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.
    • Severe metabolic acidosis is a rare complication of acetazolamide therapy.

    Observation:

    • A 61-year-old patient on oral acetazolamide for glaucoma developed altered mental status.
    • Physical examination revealed Kussmaul respirations, and arterial blood gases showed severe metabolic acidosis (pH 7.23, bicarbonate 6 mEq/L).
    • Other causes of acidosis were excluded, and the patient improved after discontinuation of acetazolamide.

    Findings:

    • This is the first reported case measuring plasma and whole blood acetazolamide concentrations in a patient with severe acidosis.
    • Acetazolamide concentrations were significantly elevated (serum 26.38 mcg/ml, whole blood 38.84 mcg/ml) four days after the last dose.

    Related Experiment Videos

  • The patient's serum acetazolamide half-life was prolonged to 34 hours, compared to the typical 1.5-6 hours in individuals with normal renal function.

    • Implications:

    • Elevated acetazolamide levels and prolonged half-life likely contributed to the severe acidosis in this patient with renal impairment.
    • Monitoring acetazolamide concentrations may be beneficial for dose adjustment and toxicity prevention in patients with compromised renal function.
    • This case underscores the potential for severe toxicity with acetazolamide in the setting of renal insufficiency.