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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Drug Delivery: Enteral Route01:18

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Routes of Drug Administration: Enteral01:18

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[Nash absorption of drugs].

Yao xue xue bao = Acta pharmaceutica Sinica·2002
Same author

[Studies on octanol-water partition coefficient and nasal drug absorption].

Yao xue xue bao = Acta pharmaceutica Sinica·1997
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[Artificial reconstituted pulmonary surfactant used for prevention and treatment of adult respiratory distress syndrome. II. Bioluminescence method for optimizing formulation].

Yao xue xue bao = Acta pharmaceutica Sinica·1997
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[Artificial reconstituted pulmonary surfactant used for prevention and treatment of adult respiratory distress syndrome. III. Prevention in animal model].

Yao xue xue bao = Acta pharmaceutica Sinica·1997
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[Studies on HPLC method for determination of 4-methylaminoantipyrine and relative bioavailabilities of analgin nasal drops in human volunteers].

Yao xue xue bao = Acta pharmaceutica Sinica·1997
Same author

[Toxicity of drugs on nasal mucocilia and the method of its evaluation].

Yao xue xue bao = Acta pharmaceutica Sinica·1995

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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[Controlled-release drug delivery systems and sustained preparations]

N Z Xi

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |September 1, 1984
    PubMed
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    No abstract available in PubMed .

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