Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethanol-induced conditioned taste aversion to ethanol.

J D Sinclair

    Alcohol (Fayetteville, N.Y.)
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    A single ethanol injection created a lasting taste aversion to an ethanol-saccharin solution. Repeated pairings strengthened this aversion, even generalizing it to ethanol alone, demonstrating conditioned taste aversion.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predictors for the efficacy of naltrexone treatment in alcohol dependence: sweet preference.

    Alcohol and alcoholism (Oxford, Oxfordshire)·2011
    Same author

    Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: a factorial double-blind, placebo-controlled trial.

    Journal of clinical psychopharmacology·2001
    Same author

    Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism.

    Alcohol and alcoholism (Oxford, Oxfordshire)·2001
    Same author

    Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats.

    Alcohol (Fayetteville, N.Y.)·2000
    Same author

    Brain ethanol levels after voluntary ethanol drinking in AA and Wistar rats.

    Alcohol (Fayetteville, N.Y.)·1999
    Same author

    Dopamine release during ethanol drinking in AA rats.

    Alcoholism, clinical and experimental research·1998
    Same journal

    Regulation of amygdala and dopamine system in naïve and chronic alcohol states.

    Alcohol (Fayetteville, N.Y.)·2026
    Same journal

    The Effects of Developmental Ethanol Exposure & Postnatal Choline Supplementation on Long-Term Choline Metabolism.

    Alcohol (Fayetteville, N.Y.)·2026
    Same journal

    Early ethanol exposure during gestation and lactation disrupts gut integrity and enhances ethanol intake in C57BL/6 mice offspring.

    Alcohol (Fayetteville, N.Y.)·2026
    Same journal

    Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices.

    Alcohol (Fayetteville, N.Y.)·2026
    Same journal

    Adolescent ethanol exposure produces sex-dependent modulation of ethanol-induced analgesia and cell type-specific vlPAG activation.

    Alcohol (Fayetteville, N.Y.)·2026
    Same journal

    Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

    Alcohol (Fayetteville, N.Y.)·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Conditioned taste aversion (CTA) is a learned response where an animal avoids a flavor associated with illness.
    • Ethanol (alcohol) can induce taste aversions, but the conditioning parameters are not fully understood.

    Purpose of the Study:

    • To investigate the acquisition and generalization of conditioned taste aversion to ethanol.
    • To examine the role of pairing procedures and ethanol injections in developing CTA.
    • To assess tolerance to ethanol's hypothermic effects and its relation to conditioned drinking behaviors.

    Main Methods:

    • Rats received single or multiple pairings of a 10% ethanol-0.05% saccharin solution with ethanol injections.
    • Control groups received unpaired presentations or saccharin paired with injections.

    Related Experiment Videos

  • Tolerance to ethanol's hypothermic effects was assessed after repeated injections.

    • Main Results:

    • A single ethanol injection induced a persistent CTA to the ethanol-saccharin solution.
    • Twelve pairings resulted in a stronger aversion that generalized to a 10% ethanol solution.
    • Unpaired presentations blocked CTA acquisition.
    • Tolerance to ethanol's hypothermic effects developed but was not conditioned to the drinking fluids.

    Conclusions:

    • Ethanol can effectively condition taste aversion, with repeated pairings enhancing the effect and promoting generalization.
    • The conditioning of taste aversion to ethanol is dependent on the temporal association between ingestion and injection.
    • Tolerance to ethanol's physiological effects does not necessarily translate to conditioned behavioral responses in this context.