Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carcinogenic potency and risk assessment.

R A Squire

    Food Additives and Contaminants
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study reviews carcinogenesis risk assessment, emphasizing a comprehensive evidence-based approach over solely relying on animal data extrapolations for evaluating human cancer risk. It highlights the importance of considering all pertinent data for accurate carcinogen evaluation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A randomised, single-blind, single-centre clinical trial to evaluate comparative clinical efficacy of shampoos containing ciclopirox olamine (1.5%) and salicylic acid (3%), or ketoconazole (2%, Nizoral) for the treatment of dandruff/seborrhoeic dermatitis.

    The Journal of dermatological treatment·2002
    Same author

    Is saccharin safe? Animal testing revisited.

    Journal of the National Cancer Institute·1998
    Same author

    A quarter century of Toxicologic Pathology: a personal perspective.

    Toxicologic pathology·1997
    Same author

    Mesenchymal tumors of the mouse urinary bladder with vascular and smooth muscle differentiation.

    Toxicologic pathology·1997
    Same author

    The use of 212Pb-labeled monoclonal antibody in the treatment of murine erythroleukemia.

    International journal of radiation oncology, biology, physics·1996
    Same author

    Confounded carcinogenicity study of sodium fluoride in CD-1 mice.

    Regulatory toxicology and pharmacology : RTP·1993
    Same journal

    Update on the progress in acrylamide and furan research. Proceedings of the DG Sanco/CIAA sponsored workshop "Acrylamide" and joint DG Sanco/EFSA/DG JRC workshop "Furan in food." March 16-17, 20006 and May 19, 2006, respectively. Brussels, Belgium.

    Food additives and contaminants·2008
    Same journal

    Food additives and contaminants.

    Food additives and contaminants·2007
    Same journal

    Index of authors---volume 24.

    Food additives and contaminants·2007
    Same journal

    High-performance liquid chromatographic method for the simultaneous detection of the adulteration of cereal flours with melamine and related triazine by-products ammeline, ammelide, and cyanuric acid.

    Food additives and contaminants·2007
    Same journal

    Mycotoxin occurrence and Aspergillus flavus soil propagules in a corn and cotton glyphosate-resistant cropping systems.

    Food additives and contaminants·2007
    Same journal

    Occurrence and fate of Fusarium mycotoxins during commercial processing of oats in the UK.

    Food additives and contaminants·2007
    See all related articles

    Area of Science:

    • Toxicology
    • Risk Assessment
    • Carcinogenesis

    Background:

    • Carcinogenesis risk assessment is crucial for public health.
    • Evaluating carcinogenic potential involves diverse evidence types.
    • Current methods often overemphasize mathematical models from animal data.

    Purpose of the Study:

    • To provide an overview of carcinogenesis risk assessment.
    • To discuss the nature of evidence for human carcinogenic potential.
    • To advocate for a weight-of-evidence approach in risk assessment.

    Main Methods:

    • Review of existing literature on carcinogenesis.
    • Discussion of evidence types: mechanisms, genotoxicity, animal data.
    • Brief description of a weight-of-evidence ranking approach for carcinogens.

    Related Experiment Videos

    Main Results:

    • Human carcinogenic potential is assessed using multiple lines of evidence.
    • Genotoxicity and mechanistic data are important alongside animal studies.
    • A comprehensive approach is superior to sole reliance on mathematical extrapolations.

    Conclusions:

    • Risk assessment for carcinogenesis requires integrating all relevant data.
    • Weight-of-evidence offers a more robust framework for evaluating carcinogens.
    • Prioritizing comprehensive evidence improves the accuracy of human cancer risk assessment.