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A versatile computer-controlled biological stimulus sequencer.

G Boyechko, D Bose

    Journal of Pharmacological Methods
    |August 1, 1984
    PubMed
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    A new computer-controlled stimulus sequencer, compatible with common microcomputers, offers flexible train creation and real-time editing. This system enhances experimental control and data acquisition capabilities for researchers.

    Area of Science:

    • Neuroscience
    • Computer Science
    • Engineering

    Background:

    • Traditional stimulus generation methods can be inflexible.
    • Need for adaptable and precise stimulus control in research.
    • Existing systems may lack compatibility with common microcomputers.

    Purpose of the Study:

    • To develop a versatile computer-controlled stimulus sequencer.
    • To enable control via inexpensive 8-bit microcomputers.
    • To provide flexible train generation and real-time editing.

    Main Methods:

    • Utilized Rockwell Versatile Interface Adapter (VIA) chip and a 12-bit digital-to-analog converter (DAC).
    • Developed software in Basic and machine language (EPROM) for turn-key operation.
    • Implemented memory-efficient storage and link-list chaining for stimulus trains.

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  • Incorporated manual and program control for train parameters and real-time editing.
  • Generated trigger pulses for oscilloscope pre-triggering.
  • Integrated external signal detection for adaptive parameter modification.

    • Main Results:

    • Successfully created a computer-controlled stimulus sequencer.
    • Demonstrated compatibility with Apple and Radio Shack Color Computer.
    • Enabled creation and sequencing of numerous unique stimulus trains.
    • Allowed real-time editing and modification of stimulus parameters.
    • Provided interrupt-driven operation for efficient processing.

    Conclusions:

    • The developed stimulus sequencer offers a flexible and cost-effective solution for experimental control.
    • Its compatibility with common microcomputers broadens accessibility for researchers.
    • The system facilitates complex stimulus train generation and real-time manipulation, enhancing experimental design.