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Diabinese-Dialume: a potential catastrophe.

T V Whelan, M D Mahoney, R D Handy

    Uremia Investigation
    |January 1, 1984
    PubMed
    Summary
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    A nondiabetic patient inadvertently received chlorpropamide, an oral hypoglycemic drug. Hemodialysis was ineffective, and prolonged dextrose therapy was needed due to profound hypoglycemia.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Endocrinology

    Background:

    • Accidental administration of oral hypoglycemic agents can occur in clinical practice.
    • Renal insufficiency may alter drug metabolism and excretion.
    • Accurate medication reconciliation is crucial to prevent adverse events.

    Observation:

    • A nondiabetic patient with renal insufficiency received chlorpropamide instead of aluminum hydroxide.
    • The patient experienced profound hypoglycemia.
    • Hemodialysis did not effectively remove chlorpropamide from the serum.

    Findings:

    • Chlorpropamide causes significant hypoglycemia in nondiabetic individuals.
    • Hemodialysis is not an effective method for clearing chlorpropamide in cases of overdose or inadvertent administration.

    Related Experiment Videos

  • Prolonged intravenous dextrose infusions are required to manage chlorpropamide-induced hypoglycemia.

    • Implications:

    • Reinforces the need for vigilant medication review, especially in patients with renal impairment.
    • Highlights the potential severity of chlorpropamide's hypoglycemic effect in non-diabetic individuals.
    • Suggests alternative management strategies for chlorpropamide toxicity, emphasizing supportive care over dialysis.