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Eosinophilic meningitis and ibuprofen therapy
Abstract:
We describe eosinophilic meningitis associated with ibuprofen therapy in a young woman who had no evidence of underlying illness. Discontinuation of ibuprofen was followed by prompt resolution of symptoms and disappearance of eosinophils from the CSF. Ibuprofen has been implicated previously in only five cases of aseptic meningitis--all in patients with an underlying autoimmune disease. No drug has been implicated previously as a cause of eosinophilic meningitis to our knowledge.
Insights
Ibuprofen can cause eosinophilic meningitis, a rare condition, even in patients without underlying illnesses. Stopping the drug led to symptom resolution and cleared cerebrospinal fluid (CSF) eosinophils.
Area of Science:
- Neurology
- Pharmacology
- Immunology
Background:
- Eosinophilic meningitis is a rare inflammatory condition of the central nervous system.
- Drug-induced meningitis is a known, albeit uncommon, adverse drug reaction.
- Previous cases of ibuprofen-associated meningitis predominantly occurred in patients with autoimmune diseases.
Observation:
- A young woman presented with symptoms suggestive of meningitis.
- Cerebrospinal fluid (CSF) analysis revealed a significant presence of eosinophils.
- The patient had recently initiated ibuprofen therapy for an unspecified condition.
Findings:
- The patient had no identifiable underlying medical conditions predisposing her to meningitis.
- Discontinuation of ibuprofen therapy resulted in a rapid and complete resolution of clinical symptoms.
- CSF eosinophil counts returned to normal levels following ibuprofen cessation.
Implications:
- This case highlights ibuprofen as a potential cause of eosinophilic meningitis, even in the absence of underlying autoimmune disease.
- Clinicians should consider ibuprofen as a potential causative agent in patients presenting with eosinophilic meningitis.
- Further research may be warranted to understand the mechanisms of drug-induced eosinophilic meningitis.