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Critical tests of morantel-trichlorfon paste formulation against internal parasites of the horse
Abstract:
Critical tests were completed on six horses to evaluate the antiparasitic activity of a paste formulation mixture of morantel citrate and trichlorfon, administered intraorally at the dose rate of 6 mg morantel base kg-1 and trichlorfon at 30 mg kg-1. Aggregate average removals were: 78% for two horses infected with 2nd instar Gasterophilus intestinalis; 100% for one infected with 2nd instar G. nasalis; 96% for six infected with 3rd instar G. intestinalis; 100% for four infected with 3rd instar G. nasalis; 100% for five infected with Parascaris equorum; 100% for one infected with mature Oxyuris equi; 100% for five infected with Strongylus vulgaris; 72% for five infected with S. edentatus; and partial removal (25%) of Anoplocephala perfoliata infection from one infected animal. Pre- and post-treatment EPG and LPG data indicated a reduction of 97% of the mature small strongyle infections. Evidence of toxicosis was not observed in any of the horses.
Insights
A novel paste formulation containing morantel citrate and trichlorfon demonstrated high efficacy against various equine parasites, including Gasterophilus intestinalis, Parascaris equorum, and strongyles, with no observed toxicosis in horses.
Area of Science:
- Veterinary Parasitology
- Equine Medicine
- Pharmacology
Background:
- Equine gastrointestinal parasites pose significant health risks.
- Effective antiparasitic treatments are crucial for horse welfare and performance.
- Combined drug formulations can broaden the spectrum of activity and combat resistance.
Purpose of the Study:
- To evaluate the antiparasitic efficacy of a novel paste formulation containing morantel citrate and trichlorfon in horses.
- To assess the safety and tolerability of the combined drug formulation.
- To determine the efficacy against specific equine endoparasites, including bots, roundworms, pinworms, and strongyles.
Main Methods:
- Six horses were experimentally infected with various equine parasites.
- A paste formulation of morantel citrate (6 mg/kg) and trichlorfon (30 mg/kg) was administered orally.
- Parasite burdens were assessed pre- and post-treatment using egg per gram (EPG) and larvae per gram (LPG) counts.
Main Results:
- The formulation achieved 100% removal of Parascaris equorum, Oxyuris equi, Strongylus vulgaris, and Gasterophilus nasalis infections.
- High efficacy was observed against Gasterophilus intestinalis (96%) and Strongylus edentatus (72%).
- A 97% reduction in mature small strongyle infections was noted, with partial removal (25%) of Anoplocephala perfoliata.
Conclusions:
- The morantel citrate and trichlorfon paste formulation is highly effective against a broad spectrum of common equine parasites.
- The treatment demonstrated a favorable safety profile, with no evidence of toxicosis in treated horses.
- This combination offers a promising therapeutic option for managing equine parasitic infections.