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Related Experiment Videos

Visual evoked potentials in rats selected for high or low self-stimulation.

M S Myslobodsky, D Levin

    Behavioural Brain Research
    |February 1, 1984
    PubMed
    Summary

    Researchers analyzed visual evoked potentials (VEPs) in high (HI) and low (LO) self-stimulation rats. HI rats showed significant VEP changes with repeated stimulation, unlike LO rats, suggesting differences in norepinephrine modulation.

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    Area of Science:

    • Neuroscience
    • Behavioral Genetics
    • Pharmacology

    Background:

    • Visual evoked potentials (VEPs) offer sensitive indices for behavioral changes.
    • Genetic selection for self-stimulation behavior creates distinct rat lines (LC2-HI and LC2-LO).
    • Understanding neurochemical underpinnings of these lines is crucial.

    Purpose of the Study:

    • To differentiate between high (HI) and low (LO) self-stimulation rat lines using VEPs.
    • To investigate the effects of D,L-amphetamine and apomorphine on VEPs in these lines.
    • To explore the role of the norepinephrinergic system in VEP modulation.

    Main Methods:

    • Analysis of secondary VEP components: slow secondary negative wave (SNW) and sensory afterdischarge (SAD).
    • Comparison of VEPs in naive HI and LO rats.

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  • Administration of D,L-amphetamine and apomorphine to assess drug effects on VEPs and behavior.
  • Monitoring of locomotion and stereotypy following drug administration.

    • Main Results:

    • LO rats exhibited a slight enhancement in SNW and SAD.
    • HI rats demonstrated a significant increase in SNW amplitude and SAD area with repeated photic stimulation.
    • D,L-amphetamine reduced SAD and SNW amplitude in both lines, preserving the initial difference.
    • Apomorphine did not affect VEP parameters despite increasing locomotion and stereotypy.

    Conclusions:

    • VEP differences between HI and LO rats suggest distinct neurobiological mechanisms.
    • Amphetamine's effect on VEPs is likely mediated by the norepinephrinergic system.
    • Norepinephrine modulation of neocortical activity may underlie the observed VEP variance between rat lines.