Related Experiment Videos
Adaptive changes to training in adipose tissue lipolysis are genotype dependent
International Journal of Obesity
|January 1, 1984
Summary
Physical training enhances adipose tissue lipolysis, independent of body fat percentage. The genetic basis for stimulated lipolysis response to training suggests individual predispositions to exercise benefits.
Area of Science:
- Exercise Physiology
- Human Metabolism
- Genetics
Background:
- Adipose tissue morphology and metabolism are influenced by both genetics and physical training.
- Understanding these influences is crucial for metabolic health and personalized exercise prescriptions.
Purpose of the Study:
- To investigate the independent effects of heredity and physical training on adipose tissue characteristics.
- To determine if training-induced changes in lipolysis have a genetic component.
Main Methods:
- Studied monozygotic twins to assess genetic influences.
- Utilized adipose tissue biopsies and isolated fat cell analysis.
- Measured basal and stimulated lipolysis before and after a 20-week ergocycle training program.
Main Results:
- Significant genetic resemblance in adipose tissue traits was observed pre-training.
- Training increased maximal oxygen uptake (VO2 max) but not body fat or adipocyte diameter.
- Training significantly enhanced basal, submaximal, and maximal lipolysis, with identical responses in monozygotic twin pairs for stimulated lipolysis.
Conclusions:
- Physical training improves adipose tissue lipolysis independent of changes in overall fatness.
- The sensitivity of stimulated lipolysis to training exhibits a genetic basis, suggesting inherited factors influence individual responses to exercise.