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Related Experiment Videos

Plasma sex hormone-binding globulin levels decrease during the second decade of life irrespective of pubertal status.

S K Cunningham, T Loughlin, M Culliton

    The Journal of Clinical Endocrinology and Metabolism
    |May 1, 1984
    PubMed
    Summary
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    Pubertal decline in sex hormone-binding globulin (SHBG) occurs in males regardless of androgen levels. This suggests other factors, not just androgens, control SHBG during puberty.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Hormone Regulation

    Background:

    • Plasma sex hormone-binding globulin (SHBG) and sex steroids influence the biologically active free steroid fraction.
    • Androgens are known to decrease SHBG levels, while estrogens increase them.
    • The pubertal decrease in SHBG in males has been traditionally attributed to rising androgen levels.

    Purpose of the Study:

    • To investigate the relationship between plasma SHBG and androgens in specific patient groups.
    • To determine if androgen activity is the sole driver of SHBG decline during puberty.

    Main Methods:

    • Studied four men with untreated isolated gonadotropin deficiency.
    • Examined two 46 XY siblings with complete androgen insensitivity.
    • Analyzed plasma SHBG and androgen levels in relation to age.

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    Main Results:

    • A significant inverse correlation between SHBG levels and age was observed in patients with isolated gonadotropin deficiency (r = -0.9, P < 0.001).
    • No correlation was found between SHBG levels and testosterone, androstenedione, or dehydroepiandrosterone-sulfate in these patients.
    • Phenotypic females with complete androgen insensitivity showed a marked decline in SHBG levels during adolescence, despite impaired androgen action.

    Conclusions:

    • The pubertal fall in SHBG levels is not solely dependent on androgen activity.
    • Unidentified factors likely regulate SHBG levels during the second decade of life.
    • This challenges the established understanding of SHBG regulation during male puberty.