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Plasma testosterone transport in primates.

M Pugeat, B Rocle, G P Chrousos

    Journal of Steroid Biochemistry
    |January 1, 1984
    PubMed
    Summary
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    Testosterone-estradiol binding globulin (TeBG) is present across all primates, but its binding characteristics vary. New World primates show higher TeBG capacity and lower affinity, linked to elevated testosterone levels and potential steroid hormone resistance.

    Area of Science:

    • Primate evolution
    • Biochemistry
    • Endocrinology

    Background:

    • Plasma testosterone-estradiol binding globulin (TeBG) is a conserved glycoprotein across primate species.
    • TeBG exhibits similar electrophoretic mobility in polyacrylamide gels among primates.
    • Understanding TeBG's role is crucial for primate reproductive biology and steroid hormone regulation.

    Purpose of the Study:

    • To investigate the evolutionary conservation and functional variations of TeBG in primate plasma.
    • To compare TeBG binding characteristics between Old World primates, New World primates, and prosimians.
    • To correlate TeBG binding parameters with plasma testosterone concentrations and potential steroid hormone resistance.

    Main Methods:

    • Analysis of plasma TeBG binding capacity and affinity for testosterone using radioligand binding assays.

    Related Experiment Videos

  • Polyacrylamide gel electrophoresis to assess TeBG mobility.
  • Measurement of total and unbound plasma testosterone concentrations.

    • Main Results:

    • TeBG was found in all primate groups studied (Old World, New World, and prosimians).
    • New World primates exhibited higher TeBG binding capacity and lower affinity for testosterone compared to Old World primates.
    • Prosimian TeBG binding parameters showed significant variation.
    • Elevated unbound plasma testosterone concentrations were observed in New World primates, correlating with altered TeBG characteristics.

    Conclusions:

    • TeBG is a highly conserved protein in primate evolution, despite significant variations in its binding properties.
    • Altered TeBG binding in New World primates is associated with high unbound testosterone levels.
    • These findings suggest a potential link between TeBG changes and generalized steroid hormone resistance in certain primate species.